The Derek Anderson era with the Buffalo Bills (yes http://www.buffalobillsteamonline.com/phillip-gaines-jersey , Sunday when the Bills (2-4) travel to play the Indianapolis Colts (1-5) in a match-up of teams desperate for a win. This Week 7 showdown, Buffalo’s third straight vs. an AFC South foe, doesn’t carry much national appeal. Only fans living in the Buffalo and Indianapolis television markets will get to watch the game as CBS’ featured 1 p.m. Eastern telecast.The Bills opened as a 7.5-point underdog against Andrew Luck and the Colts. Buffalo has not seen an opposing signal-caller throw for 300 or more yards in its last 15 games, the longest current streak in the league. Will Luck snap that streak and pass for 300 yards for the fourth straight game, or will the revamped Bills secondary slow down the aerial attack of Indianapolis? The Colts found a running game in a 42-34 Week 6 loss to the New York Jets, as Marlon Mack rushed for 89 yards on 12 carries, but the Bills will also bring an improving run defense into the game. Since Week 2, the run defense has gone from 22nd to 8th in yards per game (from 113 to 92.5 yards per game).This will be the 70th meeting all-time between these former AFC East rivals. Buffalo leads the all-time series 37-31-1, including prevailing 13-7 in overtime at snowy New Era Field on Dec. 10, 2017, a game the Bills won when LeSean McCoy rambled in from 21 yards out late in the overtime period.The last time the Bills traveled to Indianapolis http://www.buffalobillsteamonline.com/stephen-hauschka-jersey , the Colts pulled out a 20-13 win on Nov. 25, 2012. Luck tossed an eight-yard TD pass to T.Y. Hilton for a 20-6 lead, his only TD pass of the game, and the Colts prevailed despite C.J. Spiller rushing for 107 yards on 14 carries, Stevie Johnson catching six passes for 106 yards, and Mario Williams posting a three-sack game. Here’s how to watch the game from home:TV ScheduleDate: Sunday, October 21, 2018Time: 1 p.m. EasternChannel: The game will be carried locally on CBS on WIVB 4 in Buffalo, WROC 8 in Rochester, WTVH 5 in Syracuse and Utica, WENY 36-2 in Elmira Youth LeSean McCoy Jersey , and WBNG 12 in Binghamton and Elmira. View the broadcast map.Announcers: Spero Dedes (play-by-play) and Adam Archuleta (analyst). Location: Lucas Oil Stadium | Indianapolis, IndianaRadio: WGR 550AM (Buffalo), WCMF 96.5 FM and WROC 950 AM (Rochester), Fan 590 AM (Toronto), WTKW 99.5 FM and WKTV 105.5 FM (Syracuse), and the rest of the Buffalo Bills Radio Network.Radio Play-by-Play: John Murphy and Mark Kelso in the booth with sideline reporter Sal Capaccio.Online: NFL Game Pass, NFL.com Game CenterFriday Injury Report: Buffalo Bills: Full participant: G Vladimir Ducasse knee, DE Trent Murphy (knee). Did not practice: QB Josh Allen (right elbow), RB Taiwan Jones (neck). Game day status: Ducasse and Murphy are expected to play. Allen and Jones are out. Indianapolis Colts: Full participant: WR T.Y. Hilton (chest/hamstring), OT Margus Hunt (knee), CB Chris Milton (hamstring) Youth Charles Clay Jersey , OT Al Woods (rest). Limited participant: S Clayton Geathers (concussion/neck), CB Arthur Maulet (hip), TE Erik Swoope (knee). Did not practice: DT/DE Denico Autry (hamstring), TE Jack Doyle (hip), WR Ryan Grant (ankle), LB Darius Leonard (ankle), RB Robert Turbin (shoulder), Game day status: Maulet, Milton, and Swoope are questionable, Autry Youth Kelvin Benjamin Jersey , Doyle, Geathers, Grant, and Turbin are out. The Buffalo Bills host the New England Patriots for the first Monday Night Football game in Buffalo since the 2008 season. While the Bills are merely looking to stay at least somewhat competitive in games, the Patriots are eyeing their tenth consecutive AFC East Division Championship. Here’s what to watch for on Monday night at New Era Field. Tom BradyThe reports of Tom Brady’s imminent demise look to be premature. Coming off an incredible Super Bowl performance, Tom Brady has the Patriots poised for another shot at winning it all. They’re 5-2 and have a one-game lead in the AFC East. Brady will be looking to extend his six-game winning streak at New Era Field/Ralph Wilson Stadium. The last time the Bills won six consecutive home games was in the 1998 season; Brady’s junior year at Michigan.Buffalo’s defenseBefore last week, the Bills’ defense looked like it might be able to carry a historically bad offense to at least a few wins. Then they put up an absolute dud against the Indianapolis Colts. Now, they have one of the toughest match-ups of the season—the fifth-best offense in the league and the greatest quarterback of all time. If they could somehow make Tom Brady look like Week 2 Kirk Cousins it would greatly increase the chances of the Bills pulling off another incredible upset. Thurman Thomas’s number retirementIt’s been a long time coming, but the Bills will finally retire Thurman Thomas’s number 34. He’ll join his former teammates Jim Kelly (12) and Bruce Smith (78) as the only Bills to have their numbers officially retired by the organization. This will likely be the biggest highlight of the night for the Bills.